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Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 601-607 doi: 10.1007/s11684-018-0648-6

Abstract: Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity

Keywords： diet genetic susceptibility obesity interaction

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Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 146-161 doi: 10.1007/s11684-014-0373-8

Abstract: Lifestyle change fuels obesity, but genetic factors cause more than 50% of average variations in obesityAs of this writing, more than 73 obesity susceptibility loci have been identified in ethnic groups through

Keywords： obesity genetics genome-wide association studies body mass index fat mass- and obesity-associated gene

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Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 320-326 doi: 10.1007/s11684-007-0062-y

Abstract: The aim of this study was to explore the association of the genetic polymorphism of and with the susceptibilityThe genetic polymorphism in may be associated with the risk of CBP in the Chinese occupational populationand further research is needed for the association between the genetic polymorphism in and the susceptibility

Keywords： case-control rs2854451 regression analysis haplotype further research

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Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Frontiers of Engineering Management 2016, Volume 3, Issue 1, Pages 30-38 doi: 10.15302/J-FEM-2016008

Abstract: It is suggested that the accident-prone drivers may have the idiosyncrasy of susceptibility.

Keywords： accident proneness genome-wide association study (GWAS) dopamine (DA) ACTH susceptibility gene traffic

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DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

Wei Wang,Ming Li,Li Wang,Xueqing Yu

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 507-516 doi: 10.1007/s11684-016-0475-6

Abstract: shown the ethnic-specific association between certain human leukocyte antigen (HLA) alleles and IgAN susceptibilityThis study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibilityOur study indicated that HLA-DQB1*060101 alleles may be a potential predictor of high-risk IgAN susceptibility

Keywords： DQB1 human leukocyte antigen (HLA) IgA nephropathy haplotype association study

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility.

Keywords： esophageal squamous cell carcinoma telomere length genetic variants susceptibility genome-wide association

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Is tailored therapy based on antibiotic susceptibility effective?

Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li

Frontiers of Medicine 2020, Volume 14, Issue 1, Pages 43-50 doi: 10.1007/s11684-019-0706-8

Abstract: In this study, we assessed whether tailored therapy based on antibiotic susceptibility testing is moreFor the TATT and TABQT groups, antibiotic selection proceeded via susceptibility testing using an agar-dilutionSusceptibility testing was conducted using an agar-dilution test.

Keywords： tailored bismuth-containing quadruple therapy traditional bismuth-containing quadruple therapy antibiotic susceptibility

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Susceptibility of male and female Japanese medaka (

Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG

Frontiers of Environmental Science & Engineering 2013, Volume 7, Issue 1, Pages 77-84 doi: 10.1007/s11783-012-0466-z

Abstract: 2,4,6-trichlorophenol (2,4,6-TCP) is a widespread probable human carcinogen and has been proven to have genotoxicity in assays. However, little genotoxicity information and no micronuclei induction data for 2,4,6-TCP is available from tests, especially for sex-specific differences. Following a preliminary test, a piscine peripheral erythrocyte micronucleus assay was conducted on medaka ( ) after a 28-day exposure to 2,4,6-TCP. In the present study, the mean micronuclei (MNC) frequencies of all of the groups increased in a dose-dependent manner, which indicated the potential genotoxicity of 2,4,6-TCP. Moreover, males were found to be more susceptible compared with females after a 28-day exposure to 2,4,6-TCP in all of the dosed groups above 10 μg·L . This is the first report on the potential of micronuclei induction and a sex-susceptible effect in the peripheral erythrocytes of mature fish after 2,4,6-TCP exposure.

Keywords： 2 4 6-trichlorophenol genotoxicity Japanese medaka piscine micronucleus test in peripheral erythrocytes gender difference

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Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 768-780 doi: 10.1007/s11684-023-0982-1

Abstract: By employing echocardiography and genetic screening for the 46 genes, HCM can be classified into two

Keywords： machine learning methods hypertrophic cardiomyopathy genetic risk

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Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population

Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,

Frontiers of Medicine 2010, Volume 4, Issue 1, Pages 82-89 doi: 10.1007/s11684-010-0014-9

Abstract: Variation of individuals’ DNA repair capacity has been linked to cancer susceptibility.These findings suggest that functional polymorphisms influencing DNA repair capacity may confer susceptibility

Keywords： XPF polymorphism lung cancer

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Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between

Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen

Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 275-291 doi: 10.1007/s11684-020-0779-4

Abstract: Although genome-wide association studies have identified more than eighty genetic variants associatedwe conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibilityOur results illustrate the molecular basis of both well-studied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set

Keywords： genome-wide association study function annotation immune homologous recombination repair deficiency genetic

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Optimal design of steel skeletal structures using the enhanced genetic algorithm methodology

Tugrul TALASLIOGLU

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 4, Pages 863-889 doi: 10.1007/s11709-019-0523-9

Abstract: For this purpose, the enhanced genetic algorithm methodology named EGAwMP is utilized as an optimizationThe evolutionary search mechanism of EGAwMP is constituted on the basis of generational genetic algorithminto sub-populations and using of a radial basis neural network for dynamically adjustment of EGAwMP’s genetic

Keywords： design optimization genetic algorithm multiple populations neural network

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Research progress on genetic improvement of

Chuanping YANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 4, Pages 391-401 doi: 10.15302/J-FASE-2017183

Abstract: Over the past 30 years, effective progress has been made in genetic improvement and molecular breedingmolecular markers were developed and the high density genetic map constructed.All this research has provided a model and data for the foundation of forest genetic improvement and

Keywords： Betula platyphylla genetic improvement molecular breeding seed orchard

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Genomics and genetic breeding in aquatic animals: progress and prospects

Wenteng XU, Songlin CHEN

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 305-318 doi: 10.15302/J-FASE-2017154

Abstract: focuses on dissection of genome structure and function to provide a molecular basis for understanding the geneticprogress of aquatic animals in nine aspects, including WGS and fine mapping, construction of high density genetic

Keywords： aquaculture genomics genetic breeding progress

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Search-and-replace editing of genetic information

Yao LIU, Xingxu HUANG, Xiaolong WANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2, Pages 231-232 doi: 10.15302/J-FASE-2020322

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Title Author Date Type Operation

Interplay between diet and genetic susceptibility in obesity and related traits

Tiange Wang, Min Xu, Yufang Bi, Guang Ning

Journal Article

Advancement in genetic variants conferring obesity susceptibility from genome-wide association studies

Tao Wang,Weiping Jia,Cheng Hu

Journal Article

Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene

SUN Pin, ZHANG Zhongbin, WU Fen, WAN Junxiang, JIN Xibeng, XIA Zhaolin

Journal Article

Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Journal Article

DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

Wei Wang,Ming Li,Li Wang,Xueqing Yu

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

Is tailored therapy based on antibiotic susceptibility effective?

Jie Pan, Zhengchao Shi, Dingsai Lin, Ningmin Yang, Fei Meng, Lang Lin, Zhencheng Jin, Qingjie Zhou, Jiansheng Wu, Jianzhong Zhang, Youming Li

Journal Article

Susceptibility of male and female Japanese medaka (

Nannan LIU, Mei MA, Yiping XU, Jinmiao ZHA, Kaifeng RAO, Zijian WANG

Journal Article

Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

Journal Article

Functional XPF polymorphisms associated with lung cancer susceptibility in a Chinese population

Dian-Ke YU PhD, Chen WU MD, Wen TAN MD, Dong-Xin LIN MD,

Journal Article